Figure 4.

Chensinin-1b ameliorated the severity of DSS-induced colitis in mice. BALB/C mice received drinking water containing 4% DSS for 7 days and were simultaneously treated with chensinin-1b (1.5 or 3 mg/kg intraperitoneally) daily from day 1 to day 9. Body weight changes (A) and DAI scores (C) during DSS-induced colitis were recorded daily. Mice were euthanized on day 9. The distal colon and spleen were gathered to assess colon length (B) and spleen index (D). Colonic tissue damage was identified through H&E staining (E) and was quantified as histological scores (F). Data represent the mean ± SEM (n = 5 mice per group), with * p < 0.05 and ** p < 0.01.