HCE1	Human carboxylesterase 1
HCE2	Human carboxylesterase 2
MD	Molecular dynamics
PDB	Protein data bank
NMR	Nuclear magnetic resonance
It	Irinotecan
CPT	Camptothecin
L2	Pro-drug ligand with alkyl linker length 2
L5	Pro-drug ligand with alkyl linker length 5
L8	Pro-drug ligand with alkyl linker length 8
RMSF	Root mean square fluctuation
RMSD	Root mean square deviation
SER–HID	Model with neutral serine and histidine in the catalytic triad
SEM–HIP	Model with deprotonated serine and protonated histidine in the catalytic triad