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. 2024 Jan 29;13(2):82. doi: 10.3390/biology13020082

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Identification and validation of potential therapeutic compounds. (A) The description of top 10 promising small molecules for IBD treatment. (B) The chemical structure of the top-ranked BMS-536924. (C) The cytotoxicity of BMS-536924 on HT29 cells by CCK8 assay. The effects of BMS-536924 treatment on the expression of proinflammatory cytokines (D) IL-6 and (E) TNF-α in LPS-induced HT29 cells. Values are expressed as the means ± SD; n = 4 in each group. ### p < 0.001 vs. the NC group. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 vs. the LPS group.