Table 6.
Relevant ADC research, authors, main findings, and conclusions.
| Author | Important Results | Conclusions |
|---|---|---|
| Zulfiqar M, et al. (2013) [3] | Inverse correlation between ADC values measured within astrocytomas and survival | Lower ADC values are associated with a worse prognosis in malignant astrocytomas, independent of tumor grade |
| Yazdani M, et al. (2018) [15] | Significantly lower ADC values in the NAWM surrounding high-grade glioma than low-grade glioma | Perilesional ADC values are useful in preoperative evaluation for glioma grade |
| Horváth A, et al. (2015) [16] | Significantly elevated ADC values in the NAWM of glioma patients compared to control subjects | Higher diffusion in normal-appearing white matter of brain tumor patients may indicate tumor infiltration |
| Surov A, et al. (2017) [19] | Strong negative correlation between cellularity and ADC values in gliomas | ADC and cellularity correlation varies among different tumors |
| Chen L, et al. (2013) [20] | Strong negative correlation between the ADC and tumor cellularity, particularly in the brain | Meta-analysis confirms a correlation between ADC and tumor cellularity in patients |
| Momeni F, et al. (2021) [21] | Significantly lower ADCvalues at tumor center and edema and in patients with high-grade gliomas than those with low-grade gliomas | ADC values can help differentiate between low- and high-grade gliomas in the tumor itself and the surrounding edema |
| Catalaa I, et al. (2006) [24] | Minimal ADC values in the peritumoral tissue are lower in high-grade glioma than in low-grade glioma patients | Multi-modal imaging provides valuable information for newly diagnosed cerebral gliomas |
| Castillo M, et al. (2001) [24] | Significant differences in ADC between high-grade gliomas and low-grade gliomas. Considerable overlap between ADC values in high-grade gliomas, edema and NAWM | ADC values helped to distinguish high-grade glioma from normal tissue but could not be used to separate high-grade glioma from surrounding edema |
| Horváth A, et al. (2016) [31] | ADV values were significantly higher in the NAWM of glioma patients compared to controls. | Globally altered diffusion parameters suggest the presence of global vasogenic edema in the NAWM of glioma patients. Alternatively, some tumor infiltration might contribute to diffusion abnormalities in the NAWM, especially in the tumor-affected hemisphere. |