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. 2024 Feb 16;14(2):180. doi: 10.3390/brainsci14020180

Figure 2.

Figure 2

The role of SOD1 in the pathophysiology of ALS and its relationship with the purinergic system. The role played by SOD1 in the development of ALS in familial cases: activation of the P2X7 receptor by extracellular ATP influences the release of SOD1-G93A from NSC-34 motor neurons previously transfected with the mutant enzyme. The released enzymes can be transmitted to unaffected NSC-34 cells, thus contributing to the spread of the disease. This function of SOD1 suggests therapeutic benefits when using P2X7 antagonists in individuals affected by ALS who have this mutation.