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Phosphorylation state of the Pol II CTD is regulated during transcription. As Pol II transcribes through a gene and progresses through the stages of transcription (shown from left to right), different phosphorylation marks are added or removed to promote unique functions. The phosphorylation patterns shown here pertain to human Pol II; other organisms may exhibit slight differences in these patterns. TSS, transcription start site; PAS, polyadenylation site.
