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Strategies of exosomes for crossing the BBB. (A) Exosomes possess inherent BBB permeability. (B) Exosomes can hijack receptor-mediated transcytosis (RMT) by specific ligand-receptors binding to control transcytosis. (C) Exosomes can be modified with membrane-protein-binding peptides or neurotropic-virus-derived peptides to achieve effective delivery.
