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Schematic model of the subunits of DmPBP bound to the U1 and U6 PSEAs. DmPBP assumes a different conformation depending on whether it is bound to a U1 PSEA (left) or to a U6 PSEA (right). In comparison to the interaction with the U1 PSEA, the 49-kDa subunit lacks contacts with the extreme 3′ end of the U6 PSEA, and the 45-kDa subunit has stronger contacts with the central region of the U6 PSEA. The position of four of the five base differences between the U1 and U6 PSEAs are shown.
