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. 2024 Jan 26;5(1):136–140. doi: 10.1002/jha2.825

FIGURE 2.

FIGURE 2

MICA patient plasma samples contain elevated levels of citrullinated fibrinogen. (A) Interassay control samples 2071 gives a mean citrullination index of 2.8 with a CV of 9,6%. (B) Fibrinogen citrullination index was determined for 10 healthy controls and the MICA patient cohort. For the MICA cohort a median index of 2.21 was determined, which is significantly higher than the median of 0.85 obtained for healthy controls (p < 0.001, Mann–Whitney U‐test). (C) Citrullination index values were normalized based on fibrinogen concentration. The normalized fibrinogen index (NCI) mean was determined at 1.53, which is significantly higher than the median of 0.9 obtained for normalized healthy controls (p < 0.001, Mann–Whitney U‐test). (D) D‐dimer levels are significantly higher for cancer patients who develop venous thromboembolism (VTE) (VTE+) compared to patients who do not develop VTE (VTE‐) (Mann–Whitney U test). (E) MICA patient citrullinated fibrinogen index does not differ between VTE+ patients and VTE‐patients (Mann–Whitney U‐test). (F) The normalized citrullinated fibrinogen index does not differ between VTE+ patients and VTE‐ patients (Mann–Whitney U‐test).