TABLE 1.
Stimulation of DNA synthesis (BrdU nuclear labelling index) by antibody PAb1801 or plasmid pSVori− in senescent human fibroblasts
| Injection | LIa at the following culture ageb
|
||
|---|---|---|---|
| PDL65 | PDL65 + 5 days | PLD65 + 19 days | |
| IgG (control) | 0.9 ± 0.2 (645) | 1.0 ± 0.02 (727) | 0.8 ± 0.2 (686) |
| PAb1801 | 17.4 ± 0.4 (531) | 15.0 ± 1.6 (774) | 14.0 ± 0.5 (458) |
| Vector (control) | 1.2 ± 0.2 (607) | 0.8 ± 0.1 (304) | 0.6 ± 0.3 (610) |
| pSVori− | 25.9 ± 1.9 (680) | 20.8 ± 4.2 (395) | 28.4 ± 2.2 (747) |
a
One-hour LI; mean of at least three experiments ± SE. The total number of cells injected is given in parentheses.
b
See text for explanation.