Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Kinetic models for drug release.
| Kinetic Model | R2 | ||
|---|---|---|---|
| Equation | B1 | E1 | |
| Zero-order | Qt = Q0 + K0 t | 0.9194 | 0.6819 |
| First order | ln Qt = ln Q0 + K1 t | 0.9239 | 0.9382 |
| Higuchi | Qt = KH t 1/2 | 0.9424 | 0.8313 |
| Korsmeyer-pepas | Qt /Q∞ = Kktn | 0.9504 | 0.9612 |
R2: correlation coefficient; Qt: amount of drug released in time t; Q0: initial amount of drug in the dosage form; Q∞: total amount of drug dissolved when the dosage form is exhausted; n: release exponent; K0, K1, Kk, KH: release rate constants [52].
