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. 2024 Feb 1;15(2):199. doi: 10.3390/genes15020199

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proliferation analysis of cells in 3D and 2D Nichoid shows a decrease in proliferation at day 3 in 2D condition. (A). Top: images of the 2D Nichoid captured in widefield mode at different time points; bottom: images of representative MPM primary cells detached from the Nichoid structure at different time points. (B). Top: images of the 3D Nichoid captured in widefield mode at different time points; bottom: images of representative MPM primary cells detached from the Nichoid structure at different time points. In the cells channel, the contrast was increased to emphasize the signal/noise ratio. (C,D). Plot of cell counts performed on the entire well in 2D Nichoid (C) and 3D Nichoid (D). After day 3, a considerable decrease in proliferation is observed in the one-floor control, while, in the 3D condition, a plateau is reached. Scale bars are displayed.