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Proposed overview for the management of high-volume or risk metastatic castration-sensitive prostate cancer (CSPC). High risk definition (from LATITUDE) [7]: at least 2 of the following: ≥3 bone metastases, visceral metastases, Gleason score ≥8. High volume definition (from CHAARTED) [13]: at least 1 of the following: ≥4 bone lesions with ≥1 beyond the vertebral bodies and pelvis or visceral metastases. * = Rezvilutamide where available.
