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Summary diagram of RPA phosphorylation before and after DSBs. RPA is always phosphorylated (some sites are unknown and indicated with a ?), but after DDR is activated, RPA becomes hyperphosphorylated by the PIKK family of kinases and CDK cell cycle kinases, which phosphorylate RPA. Phosphorylation sites after DNA damage are shown in Figure 1D. Adapted from [40].
