Table 1.

Six candidate genes previously associated with primary hypertriglyceridemia in people.

Gene Symbol	Gene Name	Function
LPL	Lipoprotein lipase	Hydrolyzes circulating triglycerides [19]
APOC2	Apolipoprotein C-II	Essential cofactor for LPL activity [19,20]
APOA5	Apolipoprotein A-V	Stimulates LPL-mediated triglyceride hydrolysis [19,21]
LMF1	Lipase maturation factor 1	Essential for proper LPL function [19,22]
GPIHBP1	Glycosylphosphatidylinositol-anchored HDL binding protein 1	Facilitates LPL toward cell surface and promotes processing of triglyceride-rich lipoproteins [19,23]
APOE	Apolipoprotein E	Regulates clearance of chylomicron remnants and VLDL [10]

LPL, lipoprotein lipase; VLDL, very-low-density lipoprotein.