Table 1.
Listing of the five manufacturers from which the 28 cross-linked HA-based commercial dermal filler products were obtained. The study focused on well-established brands from highly reputable laboratories with long-term clinical track records and global product commercialization history. CE, European mark of conformity; FDA, US Food and Drug Administration; HA, hyaluronic acid; USA, United States of America.
| Parameters | Cross-Linked HA-Based Dermal Filler Product Manufacturers 1 | ||||
|---|---|---|---|---|---|
| Company Name | Allergan Aesthetics (Subsidiary of AbbVie Inc.) |
Galderma SA | Merz Aesthetics (Subsidiary of Merz Group) | Teoxane SA | Laboratoires VIVACY |
| Company Headquarters |
Irvine, CA, USA | Zug, Switzerland | Frankfurt am Main, Germany | Geneva, Switzerland | Paris, France |
| Product Brand of Interest | JUVÉDERM® | Restylane® | BELOTERO® | TEOSYAL RHA® | STYLAGE® |
| Product Brand Launch Year | 2000 | 1996 | 2005 | 2004 | 2008 |
| Product Types | Class III medical device | Class III medical device | Class III medical device | Class III medical device | Class III medical device |
| Product Approvals | CE-marked; FDA-approved | CE-marked; FDA-approved | CE-marked; FDA-approved | CE-marked; FDA-approved | CE-marked |
1 Laboratories specified as product legal manufacturers.