Table 2.
Comparative overview of the technical attributes and characteristics of the cross-linked HA-based commercial dermal filler products included in the study. Within each product brand, formulation-based and clinical indication specificities were found to differentiate the retained injectable products. G, gauge; HA, hyaluronic acid.
| Product Brand and Name 1 | Specified Product Clinical Uses | Needle Gauge (G) 2 | HA Concentration 3 |
Cross-Linked HA |
Contains Lidocaine | Cross-Linking Technology 4 |
|---|---|---|---|---|---|---|
| JUVÉDERM® VOLBELLA® | Fine lines; tear through | 30 G | 15 mg/mL | Yes | Yes | VYCROSS® |
| JUVÉDERM® VOLIFT® | Medium fold; lips | 30 G | 17.5 mg/mL | Yes | Yes | VYCROSS® |
| JUVÉDERM® VOLUMA® | Volumizer | 27 G | 20 mg/mL | Yes | Yes | VYCROSS® |
| JUVÉDERM® VOLUX® | Cheeks; temples; jaw line; chin volumizer | 27 G | 25 mg/mL | Yes | Yes | VYCROSS® |
| JUVÉDERM® Ultra 2 | Medium lines; lip border | 30 G | 24 mg/mL | Yes | Yes | HYLACROSS® |
| JUVÉDERM® Ultra 3 | Deep folds; lip volume | 27 G | 24 mg/mL | Yes | Yes | HYLACROSS® |
| Restylane® | Medium lines | 30 G | 20 mg/mL | Yes | No | NASHA® |
| Restylane® | Medium lines | 29 G | 20 mg/mL | Yes | No | NASHA® |
| Restylane® Lido | Medium lines | 30 G | 20 mg/mL | Yes | Yes | NASHA® |
| Restylane® Lido | Medium lines | 29 G | 20 mg/mL | Yes | Yes | NASHA® |
| Restylane® Lyft | Deep folds; volumizer | 27 G | 20 mg/mL | Yes | No | NASHA® |
| Restylane® Lyft Lido | Deep folds; volumizer | 27 G | 20 mg/mL | Yes | Yes | NASHA® |
| BELOTERO® Soft | Fine lines | 30 G | 20 mg/mL | Yes | No | CPM® |
| BELOTERO® Soft + | Fine lines | 30 G | 20 mg/mL | Yes | Yes | CPM® |
| BELOTERO® Balance | Medium lines; lip border | 30 G | 22.5 mg/mL | Yes | No | CPM® |
| BELOTERO® Balance + | Medium lines; lip border | 30 G | 22.5 mg/mL | Yes | Yes | CPM® |
| BELOTERO® Intense | Deep folds; lip volumizer |
27 G | 25.5 mg/mL | Yes | No | CPM® |
| BELOTERO® Intense + | Deep folds; lip volumizer |
27 G | 25.5 mg/mL | Yes | Yes | CPM® |
| BELOTERO® Volume | Volumizer | 30 G | 26 mg/mL | Yes | No | CPM® |
| BELOTERO® Volume + | Volumizer | 30 G | 26 mg/mL | Yes | Yes | CPM® |
| TEOSYAL RHA® 1 | Fine lines | 30 G | 15 mg/mL | Yes (mix) | Yes | Preserved Network® |
| TEOSYAL RHA® 2 | Medium folds; lip contour | 30 G | 23 mg/mL | Yes (mix) | Yes | Preserved Network® |
| TEOSYAL RHA® 3 | Deep folds; lip volumizer | 27 G | 23 mg/mL | Yes (mix) | Yes | Preserved Network® |
| TEOSYAL RHA® 4 | Volumizer | 27 G | 23 mg/mL | Yes (mix) | Yes | Preserved Network® |
| TEOSYAL Ultra Deep | Strong volumizer | 25 G | 25 mg/g | Yes | Yes | Teosyal PureSense |
| STYLAGE® S | Fine lines | 30 G | 16 mg/g | Yes | Yes | IPN-Like® + mannitol |
| STYLAGE® M | Medium folds; lip contour | 30 G | 20 mg/g | Yes | Yes | IPN-Like® + mannitol |
| STYLAGE® L | Deep folds; lip volumizer | 27 G | 24 mg/g | Yes | Yes | IPN-Like® + mannitol |
| STYLAGE® XL | Volumizer | 27 G | 26 mg/g | Yes | Yes | IPN-Like® + mannitol |
| STYLAGE® XXL | Cheeks; temples; jawline; chin volumizer | 27 G | 21 mg/g | Yes | No | IPN-Like® + mannitol |
1 All of the data used for the cross-linked HA-based hydrogel product technical comparison work were compiled from manufacturer-provided information. 2 Needles as provided by manufacturers in product secondary packaging or as specified by the manufacturer for a given product. 3 It is notable that while the HA contents of the various products are specified, details on manufacturer-specific cross-linking technologies and the degrees of system cross-linking constitute trade secrets. 4 Various degrees of polymer cross-linking frequently exist within most product brands.