Table 3.
Relationships between the concentrations of IGF proteins in ascites and the circulation of patients with ovarian cancer.
| IGF-1 | IGF-2 | IGF Bioactivity | IGFBP-4 | CT-IGFBP-4 | NT-IGFBP-4 | PAPP-A | PAPP-A2 | STC1 | STC2 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IGF-1 | r | 0.297 | 0.558 | −0.493 | −0.544 | −0.376 | 0.210 | ||||
| p | 0.002 | 0.000 | 0.027 | 0.001 | 0.000 | 0.021 | |||||
| IGF-2 | r | 0.627 | 0.248 | ||||||||
| p | 0.000 | 0.006 | |||||||||
| IGF bioactivity | r | 0.437 | 0.554 | ||||||||
| p | 0.008 | 0.001 | |||||||||
| IGFBP-4 | r | ||||||||||
| p | |||||||||||
| CT-IGFBP-4 | r | 0.319 | 0.500 | 0.485 | 0.686 | 0.745 | |||||
| p | 0.048 | 0.041 | 0.048 | 0.001 | 0.001 | ||||||
| NT-IGFBP-4 | r | 0.330 | 0.506 | 0.606 | 0.668 | ||||||
| p | 0.045 | 0.040 | 0.010 | 0.001 | |||||||
| PAPP-A | r | 0.180 | 0.223 | 0.289 | 0.310 | ||||||
| p | 0.048 | 0.013 | 0.003 | 0.001 | |||||||
| PAPP-A2 | r | 0.526 | |||||||||
| p | 0.000 | ||||||||||
| STC1 | r | 0.317 | 0.259 | −0.471 | 0.485 | 0.588 | |||||
| p | 0.001 | 0.005 | 0.045 | 0.048 | 0.000 | ||||||
| STC2 | r | −0.528 | 0.535 | 0.291 | 0.490 | ||||||
| p | 0.029 | 0.001 | 0.002 | 0.000 |
Correlation analyses of IGF proteins in ascites (italic font) and the circulation (regular font) in women with ovarian cancer. Correlation for the same protein in ascites and the circulation is shown in bold. Data are expressed as unadjusted correlation coefficient (Pearson’s correlation) r-values (top) and p-values (bottom). Only statistically significant correlations (p < 0.05) are reported. For correlations with IGFBP-4, IGFBP-4 fragments, and IGF bioactivity, analyses were only based on measurements in 20 patients. CT, C-terminal; IGF, insulin-like growth factor; IGFBP, IGF binding protein; NT, N-terminal; PAPP-A, pregnancy-associated plasma protein-A; STC2, stanniocalcin-2.