Table 4.
Log-rank analysis of all-cause mortality.
| Log-Rank Test | Low Protein Level (n = 53) | High Protein Level (n = 54) | p | ||
|---|---|---|---|---|---|
| Range (ng/mL) | Mortality, n (%) | Range (ng/mL) | Mortality, n (%) | ||
| IGF-1 | |||||
| Circulation | 62 [34–80] | 41 (77.4) | 101 [81–202] | 32 (59.3) | 0.013 |
| Ascites | 71 [31–90] | 28 (52.8) | 120 [92–211] | 45 (83.3) | <0.001 |
| IGF-2 | |||||
| Circulation | 335 [150–421] | 28 (52.8) | 565 [422–999] | 45 (83.3) | 0.005 |
| Ascites | 220 [111–312] | 29 (54.7) | 467 [313–890] | 44 (81.5) | <0.001 |
| PAPP-A | |||||
| Circulation | 0.75 [0.16–0.89] | 37 (69.8) | 1.12 [0.89–2.1] | 36 (66.7) | 0.986 |
| Ascites | 34 [12–44] | 40 (75.5) | 60 [45–101] | 33 (61.1) | 0.989 |
| PAPP-A2 | |||||
| Circulation | 0.22 [0.04–0.43] | 31 (58.5) | 1.04 [0.44–4.91] | 42 (77.8) | 0.013 |
| Ascites | 1.24 [0.18–1.70] | 34 (64.2) | 2.61 [1.77–84.4] | 39 (72.2) | 0.331 |
| STC1 | |||||
| Circulation | 0.63 [0.04–1.01] | 36 (67.9) | 1.91 [1.08–17.2] | 37 (68.5) | 0.215 |
| Ascites | 1.23 [0.08–2.09] | 34 (64.2) | 3.69 [2.12–17.3] | 39 (72.2) | 0.138 |
| STC2 | |||||
| Circulation | 28 [16–37] | 37 (69.8) | 48 [37–81] | 36 (66.7) | 0.826 |
| Ascites | 40 [16–68] | 41 (77.4) | 89 [68–235] | 32 (59.3) | 0.055 |
Number (n) and percentage (%) of events in groups based on median protein level split. p-values: log-rank test. IGF, insulin-like growth factor; PAPP-A, pregnancy-associated plasma protein-A; STC, stanniocalcin.