Table 2.
Selected studies reporting the percentage of cases, histological stage, and/or identified risk factors for HCC in cohorts of PBC patients.
| Study | % HCC Cases/PBC Patients | Histological Stage | Risk Factors |
|---|---|---|---|
| Cheng J-S [82] | 5.33 | NA | Male sex |
| Zhang X-X [81] | 4.14 | 100% cirrhosis | BMI ≥, alcohol intake |
| Deutsch M [76] | 3.77 | IV | Advanced histological stage |
| Rong G [80] | 3.75 | 80% with III/IV stage | Advanced age, male sex, co-existence of diabetes, history of HBV infection |
| Shibuya A [72] | 3.54 | III-IV | Male gender, age at diagnosis, history of blood transfusion |
| Cavazza A [69] | 3.36 | III-IV | Male gender |
| Trivedi PJ [79] | 2.69 | 42% with advanced disease | Advanced age, male sex, thrombocytopenia at 12 months, non-response to UDCA |
| Braga MH [15] | 2.66 | 95% with cirrhosis | Cirrhosis, obesity, prior azathioprine use |
| Harada H [78] | 2.41 | 10 I/17 II/14 III/8 IV | Male sex, advanced histological stage (in females) |
| Kuiper EM [77] | 2.40 | Lack of response to UDCA | |
| Jones D [70] | 2.40 | IV | Male gender |
| Floreani A [68] | 2.29 | IV | HCV, smoking |
| Jackson H [74] | 0.75 | NA | UDCA seems protective |