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[Preprint]. 2024 Feb 14:2024.02.14.580389. [Version 1] doi: 10.1101/2024.02.14.580389

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Figure 5: — a: Schematic of tRNA-Q mediated codon recognition. b: Validation of QTRT1, QTRT2, and double KO using western blots. c: Validation of tRNA-Q peak loss using LC-MS/MS. d: Analysis of the impact of tRNA-Q loss on other RNA modifications in the three KO cell lines. Arrows: significant on ANOVA analysis. Asterisk: fold change > 1.5, p < 0.05. Data normalized to Mock. e: Pearson’s correlation analysis using data from d. f: Proliferation rates of the three KO cell lines. g: Analysis of markers of ISR and RSR using western blotting.