Fig. 6: 43 preserves β-cell identity in glucolipotoxicity and prevents upregulation of ChREBPβ in high glucose and glucolipotoxicity.

a,b,f,g. mRNA fold enrichment over control low glucose in human islets, treated with 10 μM 43 for 24 h. Low-5.5 mM glucose, High-20 mM glucose; glucotox-20 mM glucose+500 μM palmitate. c, d, h. Immunostaining for PDX1, c-term ChREBP, and insulin in dispersed islets treated for 48 h with indicated treatments. e. INS-1 cells expressing luciferase driven by the human TXNIP promoter were incubated for 24 hr at the indicated glucose concentrations, in the presence or absence of 10 μM 43. Data are the means +/− SEM, n=4, ***, p<0.005, ****, p<0.001. Data are the means +/− SEM, n=3–7, *p<0.05, **p<0.01.