Patients’ characteristics classified by Severity of COVID-19 (n=147)	Severity 5 (SYMP) (Patients died) (n = 26)	Severity 4 (SYMP) (ICU + vent.) (n = 15)	Severity 3 (SYMP) (ICU) (n = 21)	Severity 2 (SYMP) (Inpatients, Reg. Adm.) (n = 64)	Severity 1 (SYMP) (ED) (n = 12)	Severity 0 (ASYMP) (n = 9)
Demographic features	Age median	65 (39-90)	52 (33-85)	53 (26-86)	57 (23-85)	51 (27-91)	27 (19-51)
	Gender (Male/Female)	19/7 (73%/27%)	9/6 (60%/40%)	13/8 (62%/38%)	37/27 (58%/42%)	5/7 (42%/58%)	5/4 (56%/44%)
	Race (% White/non-White)	6/20 (23%/77%)	8/7 (53%/47%)	13/8 (62%/38%)	25/39 (39%/61%)	7/5 (58%/42%)	2/7 (29%/71%)
Class I & II HLA status
	HLA-A*0201+	13 (50%)	8 (53%)	12 (57%)	24 (38%)	7 (58%)	7 (78%)
	HLA-DRB1*01:01+	14 (54%)	11 (73%)	12 (57%)	41 (64%)	7 (58%)	7 (78%)
Clinical parameters
	(4.8 days average for all 147 patients)
	Days between onset of symptoms and blood draw (mean)	5.9	5.7	4.6	4.5	4.1	-
	Fever (>38°C)	21 (81%)	11 (73%)	10 (48%)	30 (47%)	4 (33%)	0 (0%)
	Cough	23 (88%)	13 (87%)	16 (76%)	22 (34%)	4 (33%)	0 (0%)
	Shortness of Breath/Dyspnea	28 (100%)	15 (100%)	6 (29%)	11 (17%)	1 (8%)	0 (0%)
	Fatigue/Myalgia	9 (35%)	5 (33%)	6 (29%)	3 (5%)	3 (25%)	0 (0%)
	Headache	5 (19%)	1 (%)	4 (19%)	12 (19%)	4 (33%)	0 (0%)
	Nausea	3 (12%)	3 (20%)	3 (14%)	3 (5%)	0 (0%)	0 (0%)
	Diarrhea	7 (27%)	2 (13%)	2 (10%)	8 (13%)	0 (0%)	0 (0%)
	Anosmia/Ageusia	6 (23%)	4 (27%)	6 (29%)	17 (27%)	1 (8%)	0 (0%)
	Sore Throat	4 (15%)	1 (7%)	1 (5%)	3 (5%)	1 (8%)	0 (0%)
	ICU Admission	26 (100%)	15 (100%)	21 (100%)	0 (0%)	0 (0%)	0 (0%)
	Ventilator Support	26 (100%)	15 (100%)	0 (0%)	0 (0%	0 (0%)	0 (0%)
	White Blood Cells – (count: 103 cells /μL of blood) (average)	14.3	10.8	10.1	8.4	6.2	8.0
	Lymphocytes – (103 cells /μL of blood and %) (average)	0.7 (6%)	0.9 (10%)	1.0 (13%)	1.4 (16%)	1.6 (27%)	2.4 (29.3%)
Comorbidities
	Average number of all comorbidities	3.5	2.9	2.8	1.9	1.6	0.7
	Diabetes	14 (54%)	9 (60%)	13 (62%)	29 (45%)	4 (33%)	0 (0%)
	Hypertension (HTN)	16 (62%)	6 (40%)	9 (43%)	18 (28%)	4 (33%)	1 (11%)
	Cardiovascular disease (CVD)	17 (65%)	6 (40%)	6 (29%)	13 (20%)	3 (25%)	0 (0%)
	Coronary Artery disease (CAD)	12 (46%)	5 (33%)	7 (33%)	12 (19%)	2 (17%)	0 (0%)
	Kidney diseases (CKD/ESRD)	7 (27%)	4 (27%)	6 (29%)	7 (11%)	1 (8%)	0 (0%)
	Asthma/COPD	9 (35%)	1 (7%)	3 (14%)	12 (19%)	0 (0%)	1 (11%)
	Obesity	12 (46%)	12 (80%)	7 (33%)	29 (45%)	4 (33%)	4 (44%)
	Cancer	4(15%)	0(0%)	2(10%)	6(9%)	1(8%)	0 (0%)