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Screening data from initial SAR by differential scanning fluorimetry. Kinases are sorted by gatekeeper residues on the y-axis, against tested compounds (6–23) on the x-axis. Heatmap color code ranging from white (0% of reference thermal shift) to blue (100% of reference thermal shift). Disubstituted compounds 21–23 showed selectivity for several kinases with small gatekeeper residues (valine or threonine), which are highlighted in the black box. See Table S1 for the full set of data.
