Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2024 Feb 18:2024.02.18.580805. [Version 1] doi: 10.1101/2024.02.18.580805

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Figure 6. — Binding of selected macrocycles to EPHA2 and GAK measured by SPR. (A) Affinity fits for compounds 6 (K_D (EPHA2) = 307.0 ± 5.4; K_D (GAK) = 112.4), 23 (K_D (EPHA2) = 120.4 ± 6.5; K_D (GAK) = 7.7), 28 (K_D (EPHA2) = NA; K_D (GAK) = 49.7), and 55 (K_D (EPHA2) = 180.5 ± 5.0; K_D (GAK) = 19.2) determined by SPR . (B): Sensorgram for compounds 23, 28, and 55 for EPHA2 and GAK with kinetic-fit K_D values. SPR experiments were conducted in duplicates for EPHA2 and as a single measurement for GAK (five point dose response).