Table 4.

EC₅₀ values for prioritized compounds determined in a cellular NanoBRET target engagement assay. See Table S2 for complete data set.

	EC50 [nM]
cpd ID	EPHA2	EPHA4	GAK	ABL1	FGFR1	FLT1
23	470 ± 31	450 ± 140	20 ± 5.7	27000 ± 210	3100 ± 870	13000 ± 5400
54	370 ± 68	84 ± 32	160 ± 29	2700*	1200 ± 230	13000 ± 130
55	260 ± 73	57 ± 23	27 ± 5.6	>50000	18000 ± 1900	33000 ± 3600
56	440 ± 0.99	250 ± 57	40*	30000 ± 2300	2000*	7500*
58	250*	190 ± 45	N/A.	6400*	470*	1100*
61	340 ± 81	37 ± 12	33 ± 4.9	8400*	7600 ± 1100	17000 ± 2300
75	1600 ± 380	37 ± 12	24 ± 3.4	>50000	34000 ± 11000	42000 ± 5700
78	470*	N/A	30*	17000*	N/A.	N/A
79	1400 ± 290	60 ± 13	31 ± 2.9	32000*	9800 ± 1900	23000 ± 2600

^*Mean of one experiment performed in technical duplicates