Table 5.

Profiling of selected compounds.

	∆Tm [K]		SPR KD [nM]		NanoBRET EC50 [nM]
	EPHA2	GAK	EPHA2	GAK	EPHA2	EPHA4	GAK	t1/2 [h]	solubility [μg/mL]
6	6.7	4.9	307.0 ± 3.8	112.4	2800	N/A	N/A	N/A	N/A
23	8.1	6.6	120.4 ± 4.6	7.7	470 ± 31	450 ± 140	20 ± 5.7	6.6	N/A
28	4.3	7.0	N/A	49.7	N/A	N/A	N/A	N/A	N/A
55	7.4	7.0	180.5 ± 3.5	19.2	260 ± 73	57 ± 23	27 ± 5.6	4.6	2.24 ± 0.12
75	6.5	7.5	95.3 ± 2.0	6.2	1600 ± 380	37 ± 12	24 ± 3.4	N/A	N/A
79	8.1	8.7	126.1 ± 9.9	5.0	1400 ± 290	60 ± 13	31 ± 2.9	N/A	N/A