Table 1.
MIC and MFC values of several antifungals against S. schenckii and S. brasiliensis yeast and mycelial phases.
| CSP (4-0.06 μg/mL) |
VCZ (4-0.06 μg/mL) |
BRI (80-1.25 μM) |
ITZ (8-0.125 μg/mL) |
MFS (16-0.25 μg/mL) |
ML (16-0.25 μg/mL) |
TRB (4-0.06 μg/mL) |
AMB (8-0.125 μg/mL) |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| Ss4820 | Y | MIC | >4 | >4 | 5 | 0.25 | 2 | 2 | 1 | 2 |
| MFC | >4 | >4 | 5 | 0.5 | 2 | 2 | 1 | 2 | ||
| M | MIC | >4 | >4 | >80 | 2 | 2 | 2 | 1 | ND | |
| MFC | >4 | >4 | >80 | >8 | 2 | 2 | 1 | ND | ||
| Ss4821 | Y | MIC | >4 | >4 | 5 | 0.5 | 2 | 2 | 1 | 2 |
| MFC | >4 | >4 | 5 | 2 | 2 | 2 | 1 | 2 | ||
| M | MIC | >4 | >4 | >80 | 1 | 2 | 2 | 1 | ND | |
| MFC | >4 | >4 | >80 | >8 | 2 | 2 | 1 | ND | ||
| Ss4822 | Y | MIC | >4 | >4 | 2.5 | 0.125 | 2 | 2 | 0.5 | 2 |
| MFC | >4 | >4 | 2.5 | 0.25 | 2 | 2 | 0.5 | 2 | ||
| M | MIC | >4 | >4 | >80 | 2 | 2 | 2 | 1 | ND | |
| MFC | >4 | >4 | >80 | >8 | 2 | 2 | 1 | ND | ||
| Sb4823 | Y | MIC | >4 | >4 | 2.5 | 2 | 2 | 2 | 0.5 | 2 |
| MFC | >4 | >4 | 2.5 | >8 | 2 | 2 | 0.5 | 2 | ||
| M | MIC | >4 | >4 | >80 | 1 | 2 | 2 | 1 | ND | |
| MFC | >4 | >4 | >80 | >8 | 2 | 2 | 1 | ND | ||
| Sb4824 | Y | MIC | >4 | >4 | 2.5 | 0.5 | 2 | 2 | 0.5 | >8 |
| MFC | >4 | >4 | 2.5 | 1 | 2 | 2 | 0.5 | >8 | ||
| M | MIC | >4 | >4 | >80 | 2 | 2 | 2 | 1 | ND | |
| MFC | >4 | >4 | >80 | >8 | 2 | 2 | 1 | ND | ||
| Sb4858 | Y | MIC | >4 | >4 | 2.5 | 0.125 | 2 | 2 | 0.125 | 2 |
| MFC | >4 | >4 | 2.5 | 2 | 2 | 2 | 0.125 | 2 | ||
| M | MIC | >4 | >4 | >80 | 1 | 2 | 2 | 1 | ND | |
| MFC | >4 | >4 | >80 | >8 | 2 | 2 | 1 | ND | ||
Ss: S. schenckii, Sb: S. brasiliensis, Y: yeast phase, M: mycelial phase; CSP: caspofungin, VCZ: voriconazole, BRI: brilacidin, ITZ: itraconazole, MFS: miltefosine, ML: milteforan, TRB: terbinafine, AMB: amphotericin B; ND: not determined.