Table 2.
MIC and MFC values of MFS and ML combination with several antifungals against S. schenckii and S. brasiliensis yeast phase.
| CSP (16-0.25μg/mL) |
VCZ (16-0.25μg/mL) |
ITZ (8-0.125μg/mL) |
TRB (4-0.06μg/mL) |
BRI (20-0.03μM) |
AMB (8μg-0.125μg/mL) |
|||
|---|---|---|---|---|---|---|---|---|
| Ss4820 | Y | MIC | >16 | >16 | 0.25 | 1 | 5 | 2 |
| MFC | >16 | >16 | 0.5 | 1 | 5 | 2 | ||
| ML | MIC | >16 | >16 | <0.125 | <0.06 | 5 | 1 | |
| MFC | >16 | >16 | 0.5 | <0.06 | 5 | 1 | ||
| MFS | MIC | >16 | >16 | <0.125 | <0.06 | 5 | 1 | |
| MFC | >16 | >16 | 0.5 | <0.06 | 5 | 1 | ||
| Ss4821 | Y | MIC | >16 | >16 | 0.5 | 0.5 | 5 | 2 |
| MFC | >16 | >16 | 2 | 0.5 | 5 | 2 | ||
| ML | MIC | >16 | >16 | <0.125 | 0.25 | 5 | 0.5 | |
| MFC | >16 | >16 | 0.5 | 0.25 | 5 | 0.5 | ||
| MFS | MIC | >16 | >16 | <0.125 | 0.25 | 5 | 0.5 | |
| MFC | >16 | >16 | 0.5 | 0.25 | 5 | 0.5 | ||
| Ss4822 | Y | MIC | >16 | >16 | 0.125 | 0.5 | 5 | 2 |
| MFC | >16 | >16 | 0.25 | 0.5 | 5 | 2 | ||
| ML | MIC | >16 | >16 | ND | ND | 5 | 1 | |
| MFC | >16 | >16 | ND | ND | 5 | 1 | ||
| MFS | MIC | >16 | >16 | ND | ND | 5 | 1 | |
| MFC | >16 | >16 | ND | ND | 5 | 1 | ||
| Sb4823 | Y | MIC | >16 | >16 | 2 | 0.5 | 2.5 | 2 |
| MFC | >16 | >16 | >8 | 0.5 | 2.5 | 2 | ||
| ML | MIC | >16 | >16 | 0.5 | 0.125 | 2.5 | 0.5 | |
| MFC | >16 | >16 | >8 | 0.125 | 2.5 | 0.5 | ||
| MFS | MIC | >16 | >16 | 0.5 | 0.125 | 2.5 | 0.5 | |
| MFC | >16 | >16 | >8 | 0.125 | 2.5 | 0.5 | ||
| Sb4824 | Y | MIC | >16 | >16 | 0.5 | 0.5 | 2.5 | >8 |
| MFC | >16 | >16 | 1 | 0.5 | 2.5 | >8 | ||
| ML | MIC | >16 | >16 | 0.25 | 0.25 | 2.5 | 8 | |
| MFC | >16 | >16 | 0.25 | 0.25 | 2.5 | 8 | ||
| MFS | MIC | >16 | >16 | 0.25 | 0.25 | 2.5 | 8 | |
| MFC | >16 | >16 | 0.25 | 0.25 | 2.5 | 8 | ||
| Sb4858 | Y | MIC | >16 | >16 | 0.125 | 0.125 | 5 | 2 |
| MFC | >16 | >16 | 2 | 0.125 | 5 | 2 | ||
| ML | MIC | >16 | >16 | ND | ND | 5 | 0.25 | |
| MFC | >16 | >16 | ND | ND | 5 | 0.25 | ||
| MFS | MIC | >16 | >16 | ND | ND | 5 | 0.25 | |
| MFC | >16 | >16 | ND | ND | 5 | 0.25 | ||
Ss: S. schenckii, Sb: S. brasiliensis; Y: untreated yeasts, ML: yeast treated with milteforan (1μg/mL), MFS: yeast treated with miltefosine (1μg/mL); CSP: caspofungin, VCZ: voriconazole, ITZ: itraconazole, TRB: terbinafine, BRI: brilacidin, AMB: amphotericin B; ND: Not determined.