Table 3.
In Vitro Sulforhodamine B Assay Results for Pt2ad. Values in Parentheses are Results for Cisplatin.
| Type of Cancer | Cell Line | GI50, μM | TGI, μM | LC50, μM |
|---|---|---|---|---|
| Non-Small Cell Lung | NCI-H522 | 1.51 | 3.70 | 18.6 |
| Colon Cancer | HCC-2998 | 13.1 (10.7) | 31.7 (25.5) | 76.8 (60.8) |
| HCT-116 | 3.43 (9.24) | 15.5 (> 100) | 52.5 (> 100) | |
| HT29 | 5.99 (7.81) | 21.2 (> 100) | 63.6 (> 100) | |
| SW-620 | 3.37 (2.72) | 11.4 (> 100) | 39.2 (> 100) | |
| Central Nervous System | SF-539 | 1.47 (0.600) | 2.76 (7.67) | 5.20 (> 100) |
| Melanoma | LOX IMVI | 3.85 (0.961) | 18.4 (7.93) | 58.2 (> 100) |
| MALME-3M | 1.95 (1.85) | 8.19 (4.58) | 39.2 (> 100) | |
| M14 | 2.08 (1.71) | 14.8 (7.68) | 63.4 (35.1) | |
| MDA-MB-435 | 6.19 (2.77) | 18.4 (14.4) | 46.2 (42.7) | |
| SK-MEL-28 | 5.10 (2.99) | 17.4 (12.8) | 42.4 (99.5) | |
| UACC-62 | 3.18 (1.34) | 15.7 (9.39) | 42.0 (37.2) | |
| Ovarian Cancer | OVCAR-5 | 2.35 (4.38) | 11.9 (46.4) | 35.2 (> 100) |
| Renal Cancer | A498 | 19.7 (12.7) | 37.8 (26.4) | 72.6 (54.9) |
| RXF-393 | ---------- | 2.63 (4.58) | 5.99 (24.2) | |
| Breast Cancer | MDA-MB-231 | 1.62 (28.1) | 8.79 (> 100) | 60.2 (> 100) |
| BT-549 | 3.56 (3.36) | 16.5 (44.9) | 61.2 (> 100) | |
| MDA-MB-468 | 1.49 (0.233) | 3.85 (0.744) | 19.2 (4.50) |