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[Preprint]. 2025 Mar 9:2024.02.12.579917. Originally published 2024 Feb 13. [Version 2] doi: 10.1101/2024.02.12.579917

PMC10888955.1; 2024 Feb 13
PMC10888955.2; 2025 Mar 9

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Figure 5. — Analysis of off-targets was performed on all gene-edited cell lines and EWT_S1–5.

(A-C) NGS results of predicted off-target loci (compare Supplemental Table 8) and reference WIBR3 (parental) showing genomic location and nearest gene. All off-target events described are heterozygous, intronic and non-coding.

(D) Phylogenetic relationship of all analyzed cell lines in iSCORE-PD. Cell lines displayed in orange represent WIBR3 (parental) + WIBR3-S1,2,3 subclones and light red represents untargeted EWT_S1–8 cell lines.