Table 1.

iSCORE-PD cell line collection summary (targeted genes, mutations generated, genetic inheritance, editing approach, number of cell lines and their genotype)

				CELLS IN COLLECTION
	MUTATION	INHERITANCE	EDITING	MONOALLELIC - HETEROZYGOUS	BIALLELIC - HOMOZYGOUS
(PARK1) SNCA	A53T	Autosomal dominant	Prime editing	3	-
	A30P	Autosomal dominant	Prime editing	3	1
(PARK2) PRKN	EX3DEL	Autosomal recessive	CRISPR/Cas9 (dual guide)	-	3
(PARK6) PINK1	Q129X	Autosomal recessive	CRISPR/Cas9 (HDR)	-	3
(PARK7) DJ1	EX1–5DEL	Autosomal recessive	CRISPR/Cas9 (dual guide)	5	7
(PARK8) LRRK2	G2019S	Autosomal dominant	Prime editing, TALEN and CRISPR/Cas9 (HDR)	4	1
(PARK9) ATP13A2	FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	4
(PARK15) FBXO7	R498X/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	2
(PARK19) DNAJC6	c.801–2 A>G/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	2
(PARK20) SYNJ1	R258Q/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	2
(PARK23) VPS13C	W395C/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	-	4
	A444P/FS	Autosomal recessive	CRISPR/Cas9 (HDR)	1	2
GBA1	IVS2+1/FS	Autosomal dominant1	CRISPR/Cas9 (HDR)	4	2
Wild type	-	-		Parental + 3 independent clones
Edited wild type (EWT)	-	-	Prime editing, CRISPR/Cas9 (HDR)	Prime editing (6) + CRISPR/Cas9 (2)

¹mixed inheritance.