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[Preprint]. 2024 Feb 13:2024.02.12.24302710. [Version 1] doi: 10.1101/2024.02.12.24302710

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Figure 4. — Manhattan plots summarizing unweighted (panels A-C) and inverse probability (IP)-weighted (panels E-G) phenome-wide association studies (PheWAS) for colorectal cancer in All of Us, the Michigan Genomics Initiative, and UK Biobank using 1:2 case:non-case matched data restricted to one year prior to initial diagnosis. Panels D and H show the unweighted and IP-weighted meta-analysis PheWAS, respectively. The dashed red line represents the Bonferroni-corrected p-value threshold (−log10(0.05/number of traits)). The five traits with the smallest p-values are labeled. The upward (downward) orientation of the triangle indicates a positive (negative) association. Plots corresponding to poststratification-weighted PheWAS are presented in supplementary Figure S12.