Table 3.

Hazard Ratios of All-cause Mortality and Cause-specific Hospitalizations According to Frailty Trajectory

Comparison	MACCE HR (95% CI)	All-Cause Mortality HR (95% CI)	Acute Myocardial Infarction HR (95% CI)	Congestive Heart Failure HR (95% CI)	Ischemic Stroke HR (95% CI)
Regressors vs. Unchanged Frailty	1.58 (1.57, 1.58)	1.46 (1.46, 1.47)	1.57 (1.56, 1.58)	2.13 (2.12, 2.14)	1.52 (1.52, 1.53)
Progressors vs. Unchanged Frailty	2.30 (2.30, 2.31)	2.32 (2.32, 2.33)	1.78 (1.77, 1.79)	2.780 (2.77, 2.79)	1.78 (1.77, 1.79)

Shown are hazard ratios (HRs) and 95% confidence intervals (CIs) for all outcomes evaluated by frailty progression group. The HRs for frailty regression (claims-based frailty index slope < 0.09) and frailty progression (claims-based frailty index slope > 0.09) are compared to those with unchanged frailty (claims-based frailty index slope = 0.09). MACCE: major adverse cardiovascular or cerebrovascular event.