Table 1.
Demographic and clinical characteristics.
| Overall (n. 99) | w/ Hypo-ep (n. 38) | w/o Hypo-ep (n.61) | p-value | |
|---|---|---|---|---|
| Age [years] | 64.0 ± 10.1 | 67.8 ± 10.1 | 61.7 ± 9.5 | 0.003 |
| Female sex [n.] (%) | 26 (26.3) | 10 (26.3) | 16 (26.2) | 0.992 |
| Disease duration [years] | 6.4 ± 4.0 | 7.1 ± 4.4 | 5.9 ± 3.6 | 0.163 |
| Follow-up duration [years] | 5.9 ± 2.7 | 5.2 ± 2.5 | 6.3 ± 2.7 | 0.035 |
| Total LEDD [mg] | 662.0 ± 352.7 | 757.1 ± 381.7 | 602.8 ± 322.6 | 0.034 |
| Vasoactive therapy [n.] (%) | 31 (31.3) | 17 (44.7) | 14 (22.9) | 0.023 |
| Previous arterial hypertension [n.] (%) | 29 (29.3) | 16 (42.1) | 13 (21.3) | 0.027 |
| nOH [n.] (%) | 46 (46.5) | 31 (81.6) | 15 (24.5) | < 0.001 |
| Ambulatory blood pressure monitoring | ||||
| 24h SBP [mmHg] | 119.7 ± 10.4 | 121.5 ± 9.9 | 118.6 ± 10.6 | 0.191 |
| 24h MBP [mmHg] | 88.1 ± 7.8 | 89.5 ± 7.6 | 87.3 ± 7.8 | 0.170 |
| 24h DBP [mmHg] | 71.8 ± 7.5 | 72.3 ± 7.6 | 71.4 ± 7.4 | 0.541 |
| Daytime SBP [mmHg] | 121.6 ± 10.9 | 121.5 ± 10.0 | 121.7 ± 11.5 | 0.949 |
| Daytime MBP [mmHg] | 89.9 ± 8.6 | 90.0 ± 8.1 | 90.0 ± 8.9 | 0.968 |
| Daytime DBP [mmHg] | 73.9 ± 8.0 | 73.4 ± 7.9 | 74.2 ± 8.1 | 0.664 |
| Daytime HR [bpm] | 76.8 ± 9.5 | 76.8 ± 11.0 | 76.8 ± 8.5 | 0.982 |
| Nighttime SBP [mmHg] | 115.2 ± 14.7 | 122.1 ± 16.5 | 110.9 ± 11.7 | 0.001 |
| Nighttime MBP [mmHg] | 83.8 ± 11.0 | 89.1 ± 12.4 | 80.5 ± 8.5 | < 0.001 |
| Nighttime DBP [mmHg] | 66.9 ± 9.8 | 70.7 ± 11.5 | 64.6 ± 7.7 | 0.006 |
| Nighttime HR [bpm] | 65.3 ± 8.9 | 67.3 ± 9.3 | 64.1 ± 8.6 | 0.087 |
| Daytime SBP load [%] | 19.7 ± 20.9 | 21.4 ± 18.2 | 18.7 ± 22.6 | 0.528 |
| Daytime DBP load [%] | 17.0 ± 19.0 | 18.1 ± 17.6 | 16.4 ± 19.9 | 0.653 |
| Nighttime SBP load [%] | 33.7 ± 33.5 | 49.2 ± 36.7 | 24.0 ± 27.4 | 0.001 |
| Nighttime DBP load [%] | 34.0 ± 31.3 | 47.6 ± 35.1 | 25.5 ± 25.4 | 0.001 |
| Reverse dipping [n.] (%) | 30 (30.3) | 19 (50.0) | 11 (18.0) | 0.001 |
| w-BPV [mmHg] | 12.1 ± 3.8 | 14.6 ± 4.5 | 10.6 ± 2.2 | < 0.001 |
| Hypo-epΔ15/24 h [n.] | 2.1 ± 3.3 | 5.2 ± 3.5 | 0.3 ± 0.4 | < 0.001 |
| Office blood pressure values | ||||
| SBP (supine) [mmHg] | 130.6 ± 16.5 | 140.0 ± 17.1 | 124.8 ± 13.3 | < 0.001 |
| DBP (supine) [mmHg] | 79.1 ± 8.9 | 82.9 ± 8.5 | 76.7 ± 8.3 | < 0.001 |
| HR (supine) [bpm] | 75.8 ± 11.3 | 77.8 ± 12.8 | 74.5 ± 10.2 | 0.151 |
| SBP (orthostatism 1’) [mmHg] | 116.0 ± 21.0 | 118.2 ± 25.2 | 114.6 ± 17.9 | 0.405 |
| DBP (orthostatism 1’) [mmHg] | 74.9 ± 11.6 | 76.2 ± 12.8 | 74.1 ± 10.9 | 0.389 |
| SBP (orthostatism 3’) [mmHg] | 115.5 ± 18.4 | 116.8 ± 21.8 | 114.8 ± 16.0 | 0.600 |
| DBP (orthostatism 3’) [mmHg] | 74.7 ± 10.7 | 75.0 ± 12.1 | 74.5 ± 9.9 | 0.825 |
| HR (orthostatism) [bpm] | 84.8 ± 13.2 | 85.2 ± 15.3 | 84.5 ± 11.8 | 0.817 |
LEDD: levodopa equivalent daily dose; nOH: neurogenic orthostatic hypotension; SBP: systolic blood pressure; MBP; mean blood pressure; DBP: diastolic blood pressure; BPV: blood pressure variability; Hypo-epΔ15/24 h: hypotensive episode at Ambulatory Blood pressure Monitoring; HR: heart rate; w-BPV: weighted blood pressure variability; w/: with; w/o: without