Table 4.
Multivariable Poisson regression of severe infections up to the 1st year follow-up post-therapy
| Characteristic | IRR | 95% CI | p-value |
|---|---|---|---|
| Cohort | |||
| BsAb | – | – | |
| CAR-T | 0.43 | 0.25, 0.76 | 0.004 |
| Age | 0.99 | 0.96, 1.01 | 0.3 |
| Triple/Penta Refractory | |||
| Neither | – | – | |
| Triple | 0.90 | 0.41, 2.18 | 0.8 |
| Penta | 1.40 | 0.66, 3.33 | 0.4 |
| Prior BCMA-directed therapy | 0.62 | 0.29, 1.26 | 0.2 |
| Neutropenia ≤ 500/mm3 | 0.92 | 0.22, 2.62 | 0.9 |
| Lymphopenia ≤ 500/mm3 | 1.63 | 0.92, 2.85 | 0.089 |
| Hypogammaglobulinemia | 1.24 | 0.73, 2.12 | 0.4 |
IRR, incidence rate ratio; CI, confidence interval; BsAb, bispecific antibodies; CAR-T, chimeric antigen receptor T-cell therapy; BCMA, B-cell maturation antigen.