Figure 2.

Cisplatin affects the larvae’s curvature and decreases the locomotion speed. Cisplatin (Cisp) was added to the embryonic medium containing the larvae at 7 dpf and maintained for 48 h. Control larvae (Ctr) were placed only in the embryonic medium. (A) Cisplatin-induced alterations in the larvae curvature after 48 h of exposure compared to the control group. Rostral on the left, dorsal above. Magnitude 30×. (B). Cisplatin induced a significant decrease in larval movements. The locomotor activity of the larvae was recorded for 10 min, and the velocity (μm/s) was quantified. Statistical differences were evaluated using the t-Student test (**** p ≤ 0.0001).