Figure 1.

Abnormal protein deposition in affected brain regions during AD, PD, and ALS. In AD, cerebral cortex and hippocampus is predominantly affected and identified by amyloid plaque deposition, and a-synuclein deposition in basal ganglia is a hallmark of PD. In ALS, the brain stem and spinal cord are affected with the accumulation of TDP-43 aggregates.