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CRISPR-mediated transcriptional regulation by adding nuclease-deactivated cas9 (dcas9) to inhibit (A) or activate (B) transcription of targeted gene. CRISPR-mediated base editing involves a dCas9 or nickase Cas9 (nCas9) to bind with adenosine or cytosine (C) deaminase that changes AT to GC or CG to TA. The prime editing (D) involves nCas9 fused with RT that transcribes a part of pegRNA at target site.
