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. 2024 Feb 23;10(8):eadj9945. doi: 10.1126/sciadv.adj9945

Fig. 5. Antibody and Fc effector function profiling by systems serology following third monovalent mRNA immunization.

Fig. 5.

(A) Spike-specific IgG1, IgG2, IgG3, and IgG4 responses against spikes of WA1/2020, Gamma, and Delta variants by Luminex-based assay at baseline before boosting, at week 3 following boosting, and at month 6 following boosting in vaccinees who received third monovalent mRNA vaccines. (B) Spike-specific ADCP, ADNP, and ADCD activity against WA1/2020, Delta, and BA.1 at baseline before boosting, week 3 after boost, and month 6 after boost is shown. Medians of the MFI in red bars are depicted, and fold changes are shown numerically. Phagocytosis score for ADCP and ADNP activity is calculated as follows: phagocytosis score = % THP-1 bead-positive cells × median fluorescent intensity of bead-positive cells/10,000. LOD indicated by dotted lines represent the median MFI of an Ebolavirus glycoprotein negative control.