Figure 3.

Membrane topology of M. grisea GPCR-like proteins. The figure shows representative examples from different classes with domains that are conserved with respect to other receptors of the same class. Known Pfam domains or domains conserved between the M. grisea protein and other members of the class, as shown in Figure 2, are shaded in black. The amino-acid residue numbers that mark the boundaries of these domains are given. The location of the domains on the membrane topology shown for the M. grisea protein is the same for other proteins that share these domains. For GPR1-related proteins, sequence similarity was limited to the membrane-spanning regions and MG00532.4 had sequence similarity with other animal GPCRs between the third and the fifth membrane-spanning regions (not shown in figure).