Table 4. Internal validation.

	Development sample			Bootstrap
	B	Standard Error	Sig.	Standard Error	Sig.
Age trans	0.116	0.328	0.722	0.361	0.775
Time	0.001	0.002	0.583	0,002	0.589
Angioedema	1.193	0.164	0.000	0.173	0.001
Anxiety/Depression	0.624	0.173	0.000	0.172	0.001
AINEs	0.198	0.237	0.404	0.235	0.397
UAS7 baseline	0.062	0.011	0.000	0.011	0.001
Constant	-2,022	0.391	0.000	0.440	0.001

Internal validation was performed using Bootstrap analysis with 1.000 simulations.