Table 4.
Treatment for COVID-19 and outcomes.
| Variables | All Patients N = 3260 n (%) |
Without HF N = 3078 n (%) |
With HF N = 182 n (%) |
p-Value 1 |
|---|---|---|---|---|
| COVID-19 treatment, n (%), median (IQR) | ||||
| Corticosteroids | 2197 (67.3) | 2087 (67.8) | 110 (60.4) | 0.12 |
| Azithromycin | 1096 (33.6) | 1049 (34.1) | 47 (25.8) | 0.027 |
| Hydroxychloroquine | 690 (21.2) | 669 (21.7) | 21 (11.5) | 0.001 |
| Chloroquine | 90 (2.8) | 80 (2.6) | 10 (5.5) | 0.037 |
| Lopinavir | 234 (7.2) | 228 (7.4) | 6 (3.3) | 0.052 |
| Ritonavir | 229 (7.0) | 223 (7.2) | 6 (3.3) | 0.061 |
| Interferon | 9 (0.3) | 9 (0.3) | 0 (0.0) | >0.9 |
| Immunoglobulins | 23 (0.7) | 21 (0.7) | 2 (1.1) | 0.8 |
| Anticoagulants | 1257 (38.6) | 1154 (37.5) | 103 (56.6) | <0.001 |
| Thromboprophylaxis | 2021 (62.0) | 1928 (62.6) | 93 (51.1) | 0.002 |
| Plasmapheresis | 31 (1.0) | 29 (0.9) | 2 (1.1) | >0.9 |
| Severity and outcome variables, n (%), median (IQR) | ||||
| Vasopressors | 900 (27.6) | 837 (27.2) | 63 (34.6) | 0.037 |
| Vasopressor days | 7.0 (3.0, 12.8) | 7.0 (3.0, 13.0) | 6.5 (3.0, 12.0) | 0.8 |
| Inotropic | 336 (10.3) | 286 (9.3) | 50 (27.5) | <0.001 |
| Inotropic days | 5.0 (3.0, 10.0) | 5.0 (3.0, 9.0) | 6.0 (4.0, 10.8) | 0.086 |
| ICU hospitalization | 1745 (53.5) | 1633 (53.1) | 112 (61.5) | 0.031 |
| ICU days | 10.0 (5.0, 18.0) | 10.0 (5.0, 18.0) | 10.0 (4.8, 18.0) | 0.8 |
| IMV Requirement | 1115 (34.2) | 1054 (34.2) | 61 (33.5) | >0.9 |
| IMV days | 11.0 (6.0, 19.0) | 11.0 (6.0, 19.0) | 8.0 (4.0, 20.0) | 0.4 |
| Mortality | 831 (25.5) | 755 (24.5) | 76 (41.8) | <0.001 |
| Cardiovascular | 172 (20.7) | 140 (18.5) | 32 (42.1) | <0.001 |
| Non-cardiovascular | 659 (79.3) | 615 (81.5) | 44 (57.9) | |
| Follow-up 30 days post-discharge n = 2427 | ||||
| Rehospitalization, n (%) | 144 (7.3) | 134 (7.1) | 10 (11.5) | 0.2 |
| No data | 433 | 19 | ||
| Mortality, n (%) | 53 (2.6) | 50 (2.6) | 3 (3.3) | 0.2 |
| Cardiovascular | 11 (20.8) | 9 (18.0) | 2 (66.7) | |
| Non-cardiovascular | 42 (79.2) | 41 (82.0) | 1 (33.3) | |
1 Wilcoxon rank sum test; Pearson’s Chi-squared test. HF: heart failure. ICU: intensive care unit. IMV: invasive mechanical ventilation. IQR: interquartile range. n: number of patients.