Figure 8.

Effect of the synthesized pentacyclic benzimidazole derivatives on caspase-3 and -7 activity: Cancer cells were treated with derivative 6 (left), 19 (middle), or doxorubicin (DOXO, right) at the indicated doses for 24 h, after which caspase-3 and -7 activity was measured using a Caspase-Glo 3/7 assay in Capan-1 cells (A) and NCI-H460 cells (B). The apoptotic rate was calculated and represented as the relative fold change to the untreated control cells (UTC). The data represent the mean ± SD of two independent experiments conducted in duplicate.