Table 3.

Gibbs free energy of folding ΔG_fold of S1-subunit of S-protein and the difference ΔΔG_fold of ΔG_fold values of mutant and wild-type strain of SARS-CoV-2 coronavirus.

S1-Subunit		pH 6		pH 7		pH 9
№	Mutant	ΔGfold [kJ/mol]	ΔΔGfold [kJ/mol]	ΔGfold [kJ/mol]	ΔΔGfold [kJ/mol]	ΔGfold [kJ/mol]	ΔΔGfold [kJ/mol]
0	Wild	−95.17	0	−122.47	0	−138.28	0
1	N354R	−92.30	2.87	−119.47	2.73	−135.46	2.82
2	N354D	−96.69	−1.52	−124.62	−2.15	−140.97	−2.69
3	N354I	−89.60	5.57	−117.00	5.47	−132.29	5.99
4	D364R	−85.79	9.38	−113.54	8.93	−129.21	9.07
5	D364N	−88.94	6.23	−117.21	5.26	−132.91	5.37
6	D364Y	−88.67	6.5	−117.39	5.08	−133.39	4.89
7	R408D	−85.08	10.09	−113.49	8.98	−129.86	8.42
8	R408N	−84.26	10.91	−111.97	10.5	−128.97	9.37
9	R408I	−84.03	11.14	−113.28	9.19	−129.43	8.85
10	W436R	−91	4.17	−120.26	2.21	−136.59	1.69
11	W436E	−85.24	9.93	−113.37	9.91	−128.98	9.3
12	W436N	−90.25	4.92	−118.87	5.75	−133.87	7.1
13	P491R	−80.88	14.29	−109.64	12.83	−123.3	14.98
14	P491D	−83.64	11.53	−111.85	10.62	−128.44	9.84
15	P491N	−90.83	4.34	−119.01	3.46	−134.33	3.95