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. 2024 Feb 23;19(2):e0298802. doi: 10.1371/journal.pone.0298802

Table 3. Genes involved in transcription.

Unless otherwise noted with a citation, the function of genes was determined using GeneCards®, the human gene database or UniProtKB/Swiss site.

Gene Protein Name Function Log2 FC Adj p value
NFYA Nuclear transcription factor Y subunit alpha CCAAT binding transcription factor; regulates lipid metabolism and gluconeogenesis [61] +0.8 0.01
DUX4 Double homeobox 4 Transcriptional activator of PITX1, may regulate miRNA expression +0.8 0.02
PAX6 Paired box 6 Eye development; regulates VEGF, α4, and α5 integrin expression [62] -1.0 0.03
PITX1 Paired like homeodomain 1 Transcription factor; regulates apoptosis-related genes (ZCCHH10 and htert) and hind limb development, [63, 64] -1.1 0.02
ZNF444 Zinc finger protein 444 Activates transcription of a scavenger receptor gene involved in the degradation of Ac-LDL -1.1 0.02
CASC3 CASC3 exon junction complex subunit; Component of spliceosome -1.2 0.02
SNW1 SNW domain containing 1 Splicing and transcription, modulates TGFβ mediated transcription via Smads, coactivator that enhances glucocorticoid-mediated gene expression. -1.2 0.02
ATXN1L Ataxin 1 like Regulates transcription; represses notch signaling -1.3 0.005
FOSL1 FOS like 1 AP-1 transcription factor subunit; promotes EMT and Wnt signaling [65] -1.3 0.02