Table 2.
Relative concentrations of discriminant metabolites in samples at different times (T0, T30 and T60). Data are expressed as median and 25th–75th percentile IQR. a For each sample, the relative concentration was obtained by normalizing the molar concentration of each metabolite to the total molar concentration of all six metabolites. * Kruskal–Wallis test corrected by Benjamini–Hochberg multiple comparison. ns: not significant.
| T0 | T30 | T60 | T0 vs. T30 | T0 vs. T60 | T30 vs. T60 | |
|---|---|---|---|---|---|---|
| Metabolites (mM) a | Median (Interquartile Range) | p-Values * | ||||
| 1-Methylnicotinamide | 0.05 (0.03–0.06) |
0.08 (0.04–0.17) |
0.07 (0.05–0.11) |
0.01 | 0.02 | ns |
| Anserine | 1.24 (0.78–2.42) |
0.96 (0.53–1.24) |
1.00 (0.60–1.31) |
0.01 | 0.03 | ns |
| Hippurate | 5.65 (2.35–10.7) |
3.97 (2.05–5.50) |
3.85 (1.96–5.61) |
0.02 | 0.03 | ns |
| Lysine | 1.02 (0.59–1.72) |
0.83 (0.43–1.09) |
0.76 (0.41–1.13) |
0.02 | 0.02 | ns |
| Methyl succinate | 0.34 (0.22–0.549 |
0.24 (0.18–0.35) |
0.23 (0.18–0.30) |
0.02 | 0.01 | ns |
| Urea | 89.1 (83.5–94.0) |
93.1 (89.8–95.1) |
93.6 (90.6–95.5) |
0.04 | 0.02 | ns |