Skip to main content
. 2024 Feb 23;19(2):e0298030. doi: 10.1371/journal.pone.0298030

Fig 1. Simplified depiction of the classical and alternative RAAS pathways.

Fig 1

The classical pathway is highlighted in red and consists of angiotensin I, angiotensin II, and aldosterone. The effects of the classical RAAS pathway are listed on the right hand side of the figure. The alternative RAAS pathway is highlighted in green and consists of angiotensin I, angiotensin 1–7, and angiotensin 1–5. The effects of the alternative RAAS pathway are listed on the left hand side of the figure. Enzymes involved in the RAAS pathway are shown in blue. NEP: neprilysin; ACE: angiotensin converting enzyme; ACE2: angiotensin converting enzyme 2; AP: aminopeptidase.