Fig 3. RAS-Fingerprint^™ analytes at baseline (combined D0 and D21) and post-treatment (D7 and D28 combined) with spironolactone at 2 mg/kg/day and 4 mg/kg/day combined at 07:00 (T1) in 10 healthy purpose-bred Beagle dogs.

There was a significant increase in aldosterone (P < 0.1; Table 3). Spheres show relative concentrations of angiotensin peptides. Blue spheres generally signify that the angiotensin peptide’s action is inert, red indicates predominantly vasoconstrictive and pro-fibrotic effects, and green indicates vasodilatory and anti-fibrotic actions. Enzymes are shown as blue connecting lines between peptides.