Table 6. Effect of spironolactone treatment (combined 2 mg/kg/day and 4 mg/kg/day) in 10 healthy purpose-bred Beagle dogs using a cross-over study design on select serum biochemistry variables and SAP between baseline (combined D0 and D21) and treatment (combined D7 and D28) at 07:00 (T1; prior to feeding or morning dosing).

Data are presented as median (IQR).

Variable	Baseline	Treatment	P-value
SAP (mmHg)	133.4 (124.9–140.1)	136.8 (124.8–141.4)	1
Sodium (mEq/L)	141.5 (139.8–142.2)	142.5 (141.0–143.0)	0.73
Potassium (mEq/L)	4.2 (4.1–4.4)	4.3 (4.2–4.3)	0.97
BUN (mg/dL)	12.0 (11.0–13.0)	11.0 (11.0–12.0)	0.7
Creat (mg/dL)	0.7 (0.6–0.7)	0.7 (0.6–0.7)	1